I’ve been using Debian Trixie for a few months now. I did fresh installs of my main system and several servers (early, while it was still in testing). I just upgraded the few remaining servers that were still on Bookworm last week.
There was a bunch of little things with the servers I had to work out (especially the dovecot configuration which was really different). And some python issues with my raspberry pi at home going from python 3.11 to 3.13. It’s all running fine now, though.